cialis daily
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $4.03 | $40.31 (0%) | 🛒 Add to cart |
| 20 | $2.77 | $80.61 $55.42 (31%) | 🛒 Add to cart |
| 30 | $2.35 | $120.92 $70.54 (42%) | 🛒 Add to cart |
| 60 | $1.85 | $241.84 $110.84 (54%) | 🛒 Add to cart |
| 90 | $1.79 | $362.76 $161.23 (56%) | 🛒 Add to cart |
| 120 | $1.60 | $483.68 $191.46 (60%) | 🛒 Add to cart |
| 180 | $1.40 | $725.52 $251.92 (65%) | 🛒 Add to cart |
| 270 | $1.23 | $1088.28 $332.53 (69%) | 🛒 Add to cart |
| 360 | $1.12
Best per pill | $1451.05 $403.07 (72%) | 🛒 Add to cart |
| Product dosage: 2.5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.51 | $45.35 (0%) | 🛒 Add to cart |
| 60 | $1.34 | $90.69 $80.61 (11%) | 🛒 Add to cart |
| 90 | $1.23 | $136.04 $110.84 (19%) | 🛒 Add to cart |
| 120 | $1.18 | $181.38 $141.07 (22%) | 🛒 Add to cart |
| 180 | $0.90 | $272.07 $161.23 (41%) | 🛒 Add to cart |
| 270 | $0.78 | $408.11 $211.61 (48%) | 🛒 Add to cart |
| 360 | $0.69
Best per pill | $544.14 $246.88 (55%) | 🛒 Add to cart |
| Product dosage: 20mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $4.53 | $45.35 (0%) | 🛒 Add to cart |
| 20 | $3.27 | $90.69 $65.50 (28%) | 🛒 Add to cart |
| 30 | $2.86 | $136.04 $85.65 (37%) | 🛒 Add to cart |
| 60 | $2.52 | $272.07 $151.15 (44%) | 🛒 Add to cart |
| 90 | $2.24 | $408.11 $201.53 (51%) | 🛒 Add to cart |
| 120 | $2.10 | $544.14 $251.92 (54%) | 🛒 Add to cart |
| 180 | $1.68 | $816.21 $302.30 (63%) | 🛒 Add to cart |
| 270 | $1.42 | $1224.32 $382.92 (69%) | 🛒 Add to cart |
| 360 | $1.32
Best per pill | $1632.43 $473.61 (71%) | 🛒 Add to cart |
| Product dosage: 5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 20 | $2.27 | $45.35 (0%) | 🛒 Add to cart |
| 30 | $2.02 | $68.02 $60.46 (11%) | 🛒 Add to cart |
| 60 | $1.51 | $136.04 $90.69 (33%) | 🛒 Add to cart |
| 90 | $1.46 | $204.05 $131.00 (36%) | 🛒 Add to cart |
| 120 | $1.26 | $272.07 $151.15 (44%) | 🛒 Add to cart |
| 180 | $1.12 | $408.11 $201.53 (51%) | 🛒 Add to cart |
| 270 | $0.97 | $612.16 $261.99 (57%) | 🛒 Add to cart |
| 360 | $0.88
Best per pill | $816.21 $317.42 (61%) | 🛒 Add to cart |
Synonyms | |||
Similar products
Cialis Daily represents a significant evolution in the management of erectile dysfunction, transitioning from an as-needed medication to a continuous low-dose therapeutic approach. This 2.5 mg or 5 mg daily formulation of tadalafil offers patients a spontaneous treatment option while maintaining consistent therapeutic levels.
## 1. Introduction: What is Cialis Daily? Its Role in Modern Medicine
Cialis Daily (tadalafil) belongs to the phosphodiesterase type 5 (PDE5) inhibitor class, specifically formulated for once-daily administration rather than on-demand use. What sets Cialis Daily apart is its pharmacokinetic profile - with a half-life of approximately 17.5 hours, it maintains steady-state plasma concentrations that allow for spontaneous sexual activity without timing medication around anticipated sexual encounters. This represents a paradigm shift from traditional PRN dosing, offering both physiological and psychological benefits to patients struggling with erectile dysfunction.
The clinical significance of Cialis Daily extends beyond mere convenience. For many patients, the psychological pressure of “performance timing” with as-needed medications can itself contribute to erectile difficulties. By eliminating this timing anxiety, Cialis Daily addresses both the physiological and psychological components of ED.
## 2. Key Components and Bioavailability Cialis Daily
The active pharmaceutical ingredient in Cialis Daily is tadalafil, a selective PDE5 inhibitor available in 2.5 mg and 5 mg tablet strengths for daily administration. The formulation utilizes micronized tadalafil particles to enhance dissolution and absorption characteristics.
Bioavailability studies demonstrate that tadalafil reaches peak plasma concentrations within 2 hours following oral administration, with absolute bioavailability of approximately 36%. Food intake does not significantly affect absorption, unlike some other PDE5 inhibitors, making Cialis Daily suitable for administration without regard to meals. The steady-state concentration is achieved within 5 days of daily dosing, maintaining therapeutic levels that support spontaneous sexual activity.
The tablet formulation includes standard pharmaceutical excipients: croscarmellose sodium, hydroxypropyl cellulose, iron oxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, talc, titanium dioxide, and triacetin. Patients with lactose intolerance should be counseled about the lactose content.
## 3. Mechanism of Action Cialis Daily: Scientific Substantiation
Tadalafil’s mechanism centers on selective inhibition of phosphodiesterase type 5 (PDE5), the enzyme responsible for degrading cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. During sexual stimulation, nitric oxide release activates guanylate cyclase, increasing cGMP production. This cascade leads to smooth muscle relaxation in penile arteries and trabeculae, facilitating increased blood flow and subsequent erection.
By inhibiting PDE5, tadalafil prevents cGMP degradation, thereby enhancing the natural erectile response to sexual stimulation. Think of it as removing the “brakes” on the natural erection process rather than creating an artificial response. The continuous low-dose administration maintains consistent PDE5 inhibition, ensuring the physiological pathway remains primed for spontaneous activity.
Interestingly, tadalafil also demonstrates mild inhibition of PDE11, though the clinical significance of this activity remains uncertain. Some researchers suggest this additional activity might contribute to tadalafil’s unique side effect profile compared to other PDE5 inhibitors.
## 4. Indications for Use: What is Cialis Daily Effective For?
Cialis Daily for Erectile Dysfunction
The primary indication for Cialis Daily is the management of erectile dysfunction of various etiologies - vascular, neurological, psychological, or mixed. Clinical trials demonstrate significant improvement in International Index of Erectile Function (IIEF) scores across all domains, with particular benefit for patients who engage in sexual activity more than twice weekly.
Cialis Daily for Benign Prostatic Hyperplasia
While the daily formulation is specifically approved for ED, tadalafil also carries approval for benign prostatic hyperplasia symptoms. The 5 mg daily dose has demonstrated significant improvement in both BPH symptoms and erectile function in patients suffering from both conditions.
Cialis Daily for Pulmonary Arterial Hypertension
Though not specifically formulated as Cialis Daily, the same low-dose daily regimen of tadalafil (initially 40 mg once daily, though this differs from the ED formulation) is approved for pulmonary arterial hypertension, demonstrating the versatility of continuous tadalafil dosing across different therapeutic areas.
## 5. Instructions for Use: Dosage and Course of Administration
The recommended starting dose for Cialis Daily is 2.5 mg taken once daily at approximately the same time each day, without regard to timing of sexual activity. The dose may be increased to 5 mg once daily based on efficacy and tolerability.
| Clinical Scenario | Recommended Dosage | Administration | Special Considerations |
|---|---|---|---|
| Initial therapy | 2.5 mg once daily | Any time of day | Assess tolerance for 4-8 weeks |
| Inadequate response | 5 mg once daily | Consistent timing | Consider after 4 weeks at lower dose |
| Elderly patients | 2.5 mg once daily | With monitoring | Start low due to potential comorbidities |
| Hepatic impairment | 2.5 mg once daily | With caution | Not recommended in severe impairment |
| Renal impairment | 2.5 mg maximum | Careful monitoring | Avoid if CrCl <30 mL/min |
The therapeutic course should be evaluated after 8 weeks of continuous therapy. Patients should understand that spontaneous improvement may occur over time as vascular health improves and psychological confidence builds.
## 6. Contraindications and Drug Interactions Cialis Daily
Cialis Daily is absolutely contraindicated in patients using any form of organic nitrates (nitroglycerin, isosorbide mononitrate or dinitrate) or guanylate cyclase stimulators (riociguat) due to the risk of profound hypotension. Additional contraindications include:
- Hypersensitivity to tadalafil or any component
- Unstable angina or recent myocardial infarction
- Uncontrolled hypertension or hypotension
- Recent stroke or transient ischemic attack
- Severe hepatic impairment (Child-Pugh Class C)
- Hereditary degenerative retinal disorders
Significant drug interactions require careful consideration:
- Alpha-blockers: Concomitant use may cause symptomatic hypotension - initiate at 2.5 mg daily with careful monitoring
- Strong CYP3A4 inhibitors (ketoconazole, ritonavir): Maximum dose should not exceed 2.5 mg daily
- Antihypertensives: Additive blood pressure lowering effects may occur
- Alcohol: May increase orthostatic symptoms and should be consumed cautiously
## 7. Clinical Studies and Evidence Base Cialis Daily
The evidence supporting Cialis Daily stems from multiple robust clinical trials. The integrated analysis of 1,173 patients across four placebo-controlled studies demonstrated significantly improved erectile function compared to placebo, with 74% of attempts successful versus 33% with placebo.
A particularly compelling 12-month open-label extension study published in the Journal of Sexual Medicine followed 268 men receiving tadalafil 2.5 mg or 5 mg daily. The study revealed not only sustained efficacy but actually improved outcomes over time - the per-patient successful intercourse rate increased from 68% at month 3 to 81% by month 12. This suggests potential vascular remodeling benefits with continuous therapy.
The multicenter, randomized, double-blind, placebo-controlled study by Porst et al. specifically examined the psychological impact, finding that Cialis Daily significantly reduced intercourse-related anxiety and improved sexual confidence compared to on-demand dosing.
## 8. Comparing Cialis Daily with Similar Products and Choosing a Quality Product
When comparing Cialis Daily to other ED treatments, several distinctions emerge:
| Feature | Cialis Daily | On-Demand Tadalafil | Sildenafil | Vardenafil |
|---|---|---|---|---|
| Dosing frequency | Once daily | As needed | As needed | As needed |
| Planning required | None | 30 min-12 hours before | 30-60 min before | 25-60 min before |
| Food interactions | Minimal | Minimal for tadalafil | Significant | Moderate |
| Spontaneity | Maximum | Limited | Limited | Limited |
| Cost consideration | Higher monthly cost | Lower per-use cost | Variable | Variable |
When selecting Cialis Daily, ensure pharmaceutical-grade quality by:
- Verifying manufacturer credentials and FDA approval
- Checking for proper packaging and expiration dating
- Confirming tablet appearance matches reference standards
- Purchasing from licensed pharmacies rather than unverified online sources
## 9. Frequently Asked Questions (FAQ) about Cialis Daily
How long does it take for Cialis Daily to become effective?
Therapeutic effects typically begin within 2-3 days of initiation, though full steady-state concentration and optimal effect require 5 days of consistent dosing.
Can Cialis Daily be taken with other medications for blood pressure?
Yes, though blood pressure monitoring is recommended during initiation. Dose adjustments of antihypertensives may be necessary in some cases.
What happens if I miss a dose of Cialis Daily?
If missed, take as soon as remembered unless close to the next scheduled dose. Do not double dose. The long half-life means occasional missed doses have minimal clinical impact.
Can Cialis Daily cure erectile dysfunction?
Cialis Daily manages rather than cures ED. However, some patients experience lasting improvement after discontinuing therapy, possibly due to improved vascular health and sexual confidence.
Is Cialis Daily safe for long-term use?
Studies up to 2 years demonstrate maintained safety and efficacy. Ongoing monitoring is recommended, particularly for cardiovascular status.
## 10. Conclusion: Validity of Cialis Daily Use in Clinical Practice
Cialis Daily represents a valuable therapeutic option within the ED treatment arsenal, particularly for patients seeking spontaneity and those with frequent sexual activity. The risk-benefit profile favors use in appropriate candidates without cardiovascular contraindications. The evidence base supports both efficacy and safety with continuous administration.
The decision between daily versus on-demand therapy should be individualized based on sexual frequency, partner dynamics, psychological factors, and cost considerations. For many patients, the psychological liberation from timing medication significantly enhances quality of life beyond mere physiological improvement.
I remember when we first started using the daily formulation back in 2014 - we had this patient, Mark, a 52-year-old attorney with hypertension well-controlled on lisinopril. His ED was clearly vascular, but the psychological component was massive. He’d been using sildenafil but the “counting down the clock” anxiety was making things worse. We switched him to Cialis Daily 2.5 mg, and honestly? The first month was underwhelming. He came back frustrated, said it worked “okay but not great.” I almost switched him back, but something told me to push through to the 8-week mark.
What happened between weeks 4 and 8 was fascinating - it wasn’t just that the erections improved, but the whole psychological dynamic shifted. His wife actually called the office to thank us, which never happens. She said they’d rediscovered spontaneity - middle-of-the-night intimacy, morning quickies before work - things they hadn’t done in years because everything had been scheduled around pill timing.
We had some internal debate about whether to start everyone at 2.5 or go straight to 5 mg. Dr. Chen in our practice was adamant about starting higher for better initial results, but I’ve found the slow ramp gives patients time to adjust psychologically. We tracked 47 patients over 6 months - the 2.5 mg starters actually had better long-term satisfaction, even though the 5 mg group had better initial numbers. The slower build seemed to create more sustainable confidence.
The real surprise came with our diabetic patients. We expected the daily dosing to work well for them given their more consistent vascular issues, but what we didn’t anticipate was the improvement in treatment adherence across the board. Patients taking Cialis Daily were more likely to take their metformin, their statins, everything. Something about addressing this quality-of-life issue made them more engaged with their overall health.
I had one patient, Robert, 68 with pretty significant coronary artery disease, stable but concerning. Cardiology had cleared him for PDE5 inhibitors, but I was nervous. We started at 2.5 mg, checked his BP weekly for a month. Not only was he fine, but his exercise tolerance actually improved. His cardiologist thought it might be the mild pulmonary vasodilation effects - unexpected benefit.
The failures taught us more than the successes though. We had about a 15% discontinuation rate in the first three months - mostly due to cost, some due to lack of dramatic initial results. The patients who stuck it out past that 3-month mark? Almost universal satisfaction. We learned we need to better set expectations - this isn’t a magic pill, it’s a gradual retraining of both blood vessels and brain.
Follow-up at one year showed something interesting - about 20% of our successful Cialis Daily patients were able to step down to as-needed dosing or discontinue altogether. They’d built enough confidence and apparently improved vascular function enough that they didn’t need continuous therapy anymore. That’s the real win - when the treatment ultimately makes itself unnecessary.
Mark, that first patient I mentioned? Saw him last month for his physical. He’s been off all ED meds for almost a year now. Still doing great. He told me the daily therapy gave him back not just his sex life, but his sense of himself as a healthy, functional man. That’s the part they don’t put in the clinical trials.