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bupropion
Bupropion is an atypical antidepressant belonging to the aminoketone class, structurally distinct from SSRIs and TCAs. It functions primarily as a norepinephrine-dopamine reuptake inhibitor with minimal serotonergic activity, which explains its unique clinical profile. We’ve been using it since the 1980s, but honestly didn’t fully appreciate its mechanisms until the late 90s. Key Components and Bioavailability Bupropion The molecular structure (β-keto-amphetamine) gives it that stimulant-like effect without actual amphetamine properties. We use three main formulations: immediate-release (IR), sustained-release (SR), and extended-release (XL).
Artvigil: Enhanced Wakefulness and Cognitive Function - Evidence-Based Review
Artvigil is a wakefulness-promoting agent containing the active pharmaceutical ingredient armodafinil, the R-enantiomer of modafinil. As a eugeroic medication, it’s structurally and pharmacologically distinct from traditional stimulants like amphetamines, functioning through more selective neurotransmitter modulation. In clinical practice, we’ve observed it provides sustained alertness without the euphoric highs or crushing crashes associated with older stimulant formulations. 1. Introduction: What is Artvigil? Its Role in Modern Medicine Artvigil contains armodafinil, which represents an evolution from racemic modafinil.
bupron sr
Product Description: Bupron SR is a sustained-release formulation of bupropion hydrochloride, classified as an aminoketone antidepressant and smoking cessation aid distinct from SSRIs. The SR (sustained-release) delivery system provides biphasic absorption over 12 hours, maintaining steadier plasma concentrations than immediate-release formulations while offering more flexible dosing than the 24-hour XL version. We initially developed this intermediate-release profile specifically for patients who experienced nighttime activation with once-daily formulations but struggled with TID immediate-release compliance.
celexa
Celexa, known generically as citalopram, is a selective serotonin reuptake inhibitor (SSRI) antidepressant medication, not a dietary supplement or medical device. It’s FDA-approved for treating major depressive disorder (MDD) in adults and has been widely prescribed since the late 1990s. The drug works by increasing serotonin levels in the brain, which helps regulate mood, sleep, and appetite. Its significance in modern psychiatry lies in its relatively favorable side effect profile compared to older antidepressants like tricyclics or MAOIs, though it still carries important safety considerations including cardiac monitoring requirements at higher doses.
cenforce d
Let me walk you through my experience with Cenforce D, which has become one of our more interesting cases in men’s health management. When it first hit our formulary about three years back, I’ll admit I was skeptical - another combination product claiming to solve multiple issues with one pill. But after working with dozens of patients on it, I’ve developed a more nuanced understanding of where it fits in our therapeutic arsenal.
Champix: Evidence-Based Smoking Cessation Through Neurological Modulation
Let me walk you through our experience with Champix – or varenicline, as we know it in clinical practice. When it first hit our formulary back in 2007, we were skeptical. Another smoking cessation aid? Really? But the partial agonist mechanism targeting α4β2 nicotinic acetylcholine receptors was genuinely novel – not just replacing nicotine like patches or gum, but actually blocking the reinforcing effects while reducing withdrawal. The development team at Pfizer had stumbled onto something interesting while investigating cytisine derivatives.
contrave
Contrave represents one of the more interesting pharmacological approaches to weight management we’ve seen in recent years. It’s not a single molecule but rather a fixed-dose combination product containing naltrexone HCl and bupropion HCl in an extended-release formulation. What makes it particularly noteworthy is how it targets two separate neurological pathways involved in hunger regulation and food reward—something most previous weight loss medications never attempted. I remember when it first came across my desk, I was skeptical about combining these two particular agents, but the clinical data eventually won me over.
flibanserin
Flibanserin is a centrally-acting, multifunctional serotonin receptor agonist and antagonist that was initially investigated as an antidepressant before its serendipitous discovery for female sexual dysfunction. Marketed under the brand name Addyi, this non-hormonal oral medication represents a paradigm shift in how we approach hypoactive sexual desire disorder (HSDD) in premenopausal women. Unlike traditional therapies that focus on hormonal manipulation, flibanserin targets neurotransmitter systems in the brain regions responsible for sexual motivation and response.
fluoxetine
Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), represents one of the most widely prescribed antidepressants globally. Initially approved by the FDA in 1987, it fundamentally altered the treatment landscape for mood disorders. As a clinician who’s prescribed it for over two decades, I’ve watched its evolution from revolutionary newcomer to foundational therapy—though not without significant controversies and learning moments along the way. Fluoxetine: Comprehensive Management of Depression and Related Disorders - Evidence-Based Review 1.