More info:

• Luvox: Effective Symptom Control for OCD and Depression - Evidence-Based Review

  Fluvoxamine, marketed under the brand name Luvox among others, is a selective serotonin reuptake inhibitor (SSRI) antidepressant primarily used to treat obsessive-compulsive disorder (OCD) and major depressive disorder. It functions by increasing serotonin levels in the brain, which helps improve mood, reduce anxiety, and decrease unwanted thoughts and behaviors. Available in tablet and extended-release capsule forms, fluvoxamine is also being investigated for other conditions, including anxiety disorders and, more recently, as a potential treatment for certain inflammatory aspects of COVID-19.

• Anafranil: Effective OCD Symptom Control Through Serotonin Modulation - Evidence-Based Review

  Anafranil, known generically as clomipramine hydrochloride, is a tricyclic antidepressant (TCA) belonging to the dibenzazepine class. It’s primarily indicated for the treatment of obsessive-compulsive disorder (OCD), functioning as a potent serotonin reuptake inhibitor. Unlike many newer antidepressants, Anafranil has a well-established history in clinical psychiatry, particularly for treatment-resistant OCD cases. Its mechanism involves increasing synaptic concentrations of serotonin in the central nervous system, which helps regulate the obsessive thoughts and compulsive behaviors characteristic of OCD.

• asendin

  Let me tell you about Asendin - this isn’t your typical antidepressant monograph. I’ve been working with this medication since my residency in the late 90s, and let me be honest, it’s been quite the journey. Asendin, or amoxapine as we know it generically, occupies this interesting space between the older tricyclics and the newer SSRIs that came later. It’s like the bridge drug that never quite got the recognition it deserved, but in the right patients?

• clozaril

  Clozaril represents one of the most significant advances in treatment-resistant schizophrenia pharmacotherapy, yet remains widely misunderstood outside specialized psychiatric circles. As an atypical antipsychotic with the chemical name clozapine, it occupies a unique therapeutic niche due to its superior efficacy but complex safety profile requiring rigorous monitoring protocols. Clozaril: Superior Efficacy for Treatment-Resistant Schizophrenia - Evidence-Based Review 1. Introduction: What is Clozaril? Its Role in Modern Medicine Clozaril (clozapine) stands as the gold standard pharmacological intervention for treatment-resistant schizophrenia, defined as failure to respond adequately to at least two different antipsychotic medications.

• cymbalta

  Duloxetine hydrochloride, marketed under the brand name Cymbalta, represents a significant class of antidepressant and analgesic medications known as serotonin-norepinephrine reuptake inhibitors (SNRIs). It’s not a dietary supplement or a medical device in the traditional sense, but a prescription pharmaceutical with a complex mechanism and a broad range of approved uses, from major depressive disorder to chronic musculoskeletal pain. Its development was a gamble on the dual-reuptake inhibition hypothesis, which was still somewhat controversial when we began the clinical trials.

• Daliresp: Targeted Anti-Inflammatory Therapy for COPD - Evidence-Based Review

  Daliresp (roflumilast) represents one of the more interesting therapeutic approaches we’ve seen in pulmonary medicine over the past decade. Unlike traditional bronchodilators that work through direct smooth muscle relaxation, this phosphodiesterase-4 (PDE4) inhibitor operates through a completely different mechanism—targeting the underlying inflammatory processes in COPD. When I first encountered this medication during its clinical trials phase, our pulmonary team had significant debates about its practical utility versus established therapies. 1. Introduction: What is Daliresp?

• flexeril

  Cyclobenzaprine, marketed as Flexeril, represents one of those workhorse medications that every primary care clinic keeps in stock despite newer alternatives constantly emerging. It’s a centrally-acting muscle relaxant with structural similarities to tricyclic antidepressants, which explains both its therapeutic benefits and its problematic side effect profile. What’s fascinating about cyclobenzaprine isn’t just its mechanism—which we’ll dive into—but how it occupies this unique clinical niche where it’s simultaneously overprescribed for minor strains yet underappreciated for certain specific indications.

• Melatonin: Regulating Sleep-Wake Cycles and Beyond - Evidence-Based Review

  Melatonin is an endogenous neurohormone primarily synthesized and secreted by the pineal gland in a circadian rhythm, with peak levels occurring during the night in darkness. It plays a fundamental role in synchronizing the body’s sleep-wake cycle with the environmental light-dark cycle. In clinical practice, exogenous melatonin is utilized as a dietary supplement and, in some jurisdictions, a regulated pharmaceutical agent to address sleep disorders and other conditions related to circadian rhythm misalignment.

• Olanzapine: Effective Symptom Control for Schizophrenia and Bipolar Disorder - Evidence-Based Review

  Olanzapine stands as one of the most clinically significant atypical antipsychotics developed in the last 30 years. Initially approved by the FDA in 1996, it represented a major shift from typical antipsychotics like haloperidol, offering a vastly improved side effect profile regarding extrapyramidal symptoms. It’s a thienobenzodiazepine derivative, structurally similar to clozapine but without the agranulocytosis risk that makes clozapine a last-line option. We use it primarily for schizophrenia, bipolar mania, and as an adjunct in treatment-resistant depression.