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Pariet: Potent Acid Suppression for Gastrointestinal Health - Evidence-Based Review
Pariet, known generically as rabeprazole, is a proton pump inhibitor (PPI) medication used primarily for managing acid-related gastrointestinal disorders. It works by irreversibly inhibiting the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell, effectively suppressing gastric acid secretion. Available in delayed-release tablet form, often as enteric-coated granules to survive the stomach’s acidic environment, Pariet is prescribed for conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Aciphex: Effective Acid Suppression for GERD and Ulcer Healing - Evidence-Based Review
Aciphex is the brand name for rabeprazole sodium, a proton pump inhibitor (PPI) used primarily for managing acid-related gastrointestinal disorders. It works by irreversibly inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells, effectively suppressing gastric acid secretion. Available in delayed-release tablet form, Aciphex is prescribed for conditions like gastroesophageal reflux disease (GERD), erosive esophagitis, Helicobacter pylori eradication in combination with antibiotics, and pathological hypersecretory conditions including Zollinger-Ellison syndrome.
nexium
Nexium, known generically as esomeprazole magnesium, represents the purified (S)-isomer of omeprazole and belongs to the proton pump inhibitor (PPI) class of medications. It functions by irreversibly inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells, effectively suppressing gastric acid secretion. This mechanism provides profound and prolonged acid suppression, making it a cornerstone therapy for acid-related disorders. Its development marked a significant advancement in gastroenterology, offering improved pharmacokinetic and pharmacodynamic profiles over earlier racemic mixtures.
pepcid
Pepcid, known generically as famotidine, is an H2-receptor antagonist that’s been a mainstay in gastroenterology for decades. It works by selectively blocking histamine at the H2 receptors in the gastric parietal cells, which significantly reduces gastric acid secretion. This mechanism is crucial for managing conditions where acid control is paramount. I remember when it first came to market, there was a lot of debate among our team about whether it offered any real advantage over cimetidine, which had more drug interactions.
Prevacid: Effective Acid Reduction for GERD and Ulcer Management - Evidence-Based Review
Product Description: Prevacid (lansoprazole) represents a significant advancement in proton pump inhibitor therapy, specifically formulated as delayed-release capsules and orally disintegrating tablets for the management of acid-related gastrointestinal conditions. The distinctive purple and gray capsules contain enteric-coated granules that protect the active ingredient from gastric acid degradation, allowing targeted delivery to the parietal cells of the stomach. What’s fascinating about this formulation - and something we didn’t fully appreciate during early development - is how the delayed-release mechanism creates a therapeutic window that aligns perfectly with the proton pumps’ regeneration cycle.
prilosec
Prilosec, known generically as omeprazole, is a proton pump inhibitor (PPI) available both as a prescription medication and over-the-counter. It’s fundamentally designed to reduce stomach acid production by targeting the proton pumps in the gastric parietal cells. This mechanism makes it a cornerstone in managing acid-related disorders, from occasional heartburn to more severe conditions like erosive esophagitis. Its development marked a significant shift from H2-receptor antagonists, offering more profound and prolonged acid suppression.
Protonix: Potent Acid Suppression for GERD and Ulcer Healing - Evidence-Based Review
Protonix, known generically as pantoprazole, is a proton pump inhibitor (PPI) prescribed primarily for managing gastric acid-related disorders. It works by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system—the “proton pump”—in the gastric parietal cells, leading to a significant and prolonged reduction in basal and stimulated acid secretion. Available in both oral and intravenous formulations, it’s a cornerstone in treating conditions like gastroesophageal reflux disease (GERD), erosive esophagitis, and Zollinger-Ellison syndrome.
Ranitidine: Effective Acid Reduction for GI Disorders - Evidence-Based Review
Ranitidine, a histamine-2 (H2) receptor antagonist, has been a cornerstone in managing gastric acid-related disorders for decades. Initially developed as a prescription medication and later available over-the-counter, it works by selectively blocking H2 receptors on parietal cells in the stomach, leading to reduced basal and stimulated acid secretion. This mechanism provided relief for millions suffering from conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. However, its journey has been marked by significant safety concerns, including the detection of N-nitrosodimethylamine (NDMA), a probable human carcinogen, in some products, leading to widespread recalls and a reevaluation of its role in therapy.
zantac
Ranitidine, commonly known by its brand name Zantac, was a histamine-2 (H2) blocker medication that revolutionized the management of gastric acid-related disorders. For decades, it stood as a first-line defense against heartburn, GERD, and ulcers, offering millions rapid symptomatic relief by directly inhibiting stomach acid production at the receptor level. Its significance in both prescription and over-the-counter markets made it a household name, though its journey from medical breakthrough to global market withdrawal represents one of modern pharmacology’s most instructive case studies about drug safety, regulatory oversight, and the evolving understanding of risk-benefit profiles in widely used medications.
